食品生物技术系

利用生物信息学分析肥胖相关代谢疾病、恶性肿瘤等复杂疾病的致病机理。
（1）利用多组学以及单细胞测序技术剖析复杂疾病致病机理；
（2）食品来源天然小分子减肥、改善肥胖及代谢的机理研究；
（3）基于高光谱与近红外光谱技术的农产品及中药材产地溯源与食品掺假鉴别研究。

1.国家自然科学青年基金：多组学数据整合分析探究肝细胞癌相关RNA编辑位点及其功能影响2019.01-2021.12，项目主持人。
2.安徽省自然科学基金：基于生物数据整合的肝细胞癌患者RNA编辑组合调控模式研究，2019.07-2021.06，项目主持人。
3. 2025 年度安徽省食药用菌功能活性与资源利用联合共建重点实验室开放课题：基于近红外光谱技术建立茯苓的产品指纹图谱和掺假鉴定体系，2025.12.31-2027.12.31，项目主持人。
4. 企业委托横向课题，散射光信号处理模型开发，2025.9.1-2026.2.28，项目主持人。
5.合肥工业大学博士专项科研资助基金：肥胖小鼠升麻提取物的代谢组学分析，2018.05-2020.04，项目主持人。
6.合肥工业大学应用培育计划项目: 特色中餐料理包的研发，2019.07-2020.07，项目主持人。
7.合肥工业大学学术新人提升B计划：肥胖相关代谢疾病中关键RNA编辑位点识别及功能分析，2022.05-2023.12，项目主持人。

代表性论文
1) Chen Juan#, Zhang Cheng-hui# Tao Tao, Zhang Xian, Lin Yan, Wang Fang-bin, Liu Hui-fang*, Liu Jian*. A-to-I RNA co-editing predicts clinical outcomes and is associated with immune cells infiltration in hepatocellular carcinoma. Communications Biology, 2024 Jul 9;7(1):838.
2) Chen Juan#, Yuan Jing-Jing#, Huang Li-Na#, Shi Qiang-Qiang, Zhang Xian, Qiu Ming-Hua*, Liu Jian*. Linoleic acid metabolism is implicated in the anti-obesity effects of actein in C57BL/6 mice. Biochemical Pharmacology. 2025 Mar;233:116793.
3) Chen Juan, Liu Hui-fang, Qiao Li-bo, Wang Fang-bin, Wang Lu, Lin Yan, Liu Jian*. Global RNA editing identification and characterization during human pluripotent-to-cardiomyocyte differentiation, Molecular Therapy-Nucleic Acids, 2021, 26: 879-891.
4) Chen Juan, Wang Lu, Wang Fangbin, Liu Jian*, Bai Zhenyu*. Genomic identification of RNA editing through integrating omics datasets and the clinical relevance in hepatocellular carcinoma, Frontiers in Oncology, 2020, 10: 37.
5) Yuan Jingjing, Nian Yin, Wang Xin, Shi Qiangqiang, Shui Shanshan, Cai Hao, Lin Yan, Zhang Xian, Wang Fangbin, Chen Juan*, Qiu Minghua*, Liu Jian*. Actein ameliorates diet-induced obesity through the activation of AMPK-mediated white fat browning. Phytomedicine. 2024 Nov;134:156009.
6) Tao Tao#, Xu Yanting#, Zhang Cheng-Hui, Zhang Xian*, Chen Juan*, Liu Jian*. Single-cell transcriptomic analysis and luteolin treatment reveal three adipogenic genes, including Aspn, Htra1 and Efemp1. Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Mar;1870(2):159585.
7) Zhang Zhixin, Zhao Linlin, Wang Jiahui, Chen Hao, Lin Yan, Wang Fangbin, Wang Lu, Chen Juan*, Liu Jian*, Zhang Xian*. Luteolin, as a bidirectional ROS regulator, elevates mouse beige adipocyte browning. Biochim Biophys Acta Mol Cell Biol Lipids. 2025 Jun;1870(5):159620.
8) Wang Xin, Cai Hao, Shui Shanshan, Lin Yan, Wang Fangbin, Wang Lu, Chen Juan*, Liu Jian* . Chrysin stimulates subcutaneous fat thermogenesis in mice by regulating PDGFR alpha and microRNA expressions, Journal of Agricultural and Food Chemistry, 2021, 69(21): 5897-5906.
9) Zhou Zhou, Chen Juan*, Zhang Zhixin, Wang Fangbin, Wang Lu, Lin Yan, Zhang Xian, Liu Jian*. Solubilization of luteolin in PVP40 solid dispersion improves inflammation-induced insulin resistance in mice. European Journal of Pharmaceutical Sciences, 2022 Jul 1;174:106188.